We were quite excited to see the first shipment of Chinese sourced Sofosbuvir and Ledipasvir. A white powder and and off white powder, but what would the NMR show? Here's the NMR for Sofosbuvir which is right on the money.
Ledipasvir: mass [M+H] + 889.4195 ( < 2 ppm error)
- molecular formula - C49H54F2N8O6
Sofosbuvir: mass [M+H] + 530.1699 ( < 0.2 ppm error)
- molecular formula - C22H29FN3O9P
On the 20th May 2015 the Medicines and Healthcare products Regulatory Agency in the UK issued a Drug Safety Update titled:
Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia and heart block when taken with amiodarone.
You will find a link to it at: